Papers from the laboratory

Maira Rivera, Francesca Burgos-Bravo, Felipe Engelberger, Roi Asor, Miguel Lagos, Maximiliano Figueroa, Philipp Kurura, Cesar Ramirez-Sarmiento, Mauricio Baez, Steven Smith, Christian A.M. Wilson. Effect of temperature and nucleotide on the binding of BiP chaperone to a protein substrate. Protein Science 32(7), e4706. DOI: 10.1002/pro.4706

Maira Rivera, Are Mjaavatten, Steven Smith, Mauricio Baez, Christian A.M. Wilson. Temperature dependent mechanical folding of a protein studied by thermo-regulated optical tweezers. Biophysical Journal 122, 1-9, 2023. DOI: 10.1016/j.bpj.2022.12.034

Wendy N. Sánchez, Luka Robenson, Valentina Carrasco, Nataniel Figueroa Leigh, Francesca Burgos-Bravo, Christian A.M. Wilson, Nathalie Casanova-Morales Determination of Protein-Protein Interactions at the single-molecule level Using Optical Tweezers. Quarterly Reviews of Biophysics. Volume 55 , 2022 , e8. DOI: 10.1017/S0033583522000075

Post-translational Protein Translocation Through Membranes at the Single Molecule Level Diego Quiroga-Roger, Hilda M. Alfaro-Valdés and Christian A.M. Wilson MoyaCapítulo en el libro “Single-Molecule ScienceFrom Super-Resolution Microscopy to DNA Mapping and Diagnostics editado por Krishnarao Appasani & Raghu Kiran Appasani. Cambridge University PressPáginas 80-93. In press, publication planned for October 2020. (ISBN: 9781108423366

Hilda M. Alfaro-Valdés, Francesca Burgos-Bravo, Nathalie Casanova-Morales, Diego Quiroga‐Roger, Christian A.M. Wilson. Mechanical Properties of Chaperone BiP, the Master Regulator of the Endoplasmic Reticulum. IntechOpen DOI: 10.5772/intechopen.82080

Nathalie Casanova‐Morales, Diego Quiroga‐Roger, Hilda M. Alfaro‐Valdés, Zahra Alavi, Miguel I.A. Lagos‐Espinoza, Giovanni Zocchi, Christian A.M. Wilson Mechanical properties of BiP protein determined by nano‐rheology. Protein Science. DOI:

Aaron J. Paredes, Hilda M. Alfaro-Valdés, Christian A.M. Wilson. DNA staining method based on formazan precipitation induced by blue light exposure. Journal of Visualized Experiments (JoVE). Accepted November 16, 2017

Ramírez, M.P.; Rivera, M.; Quiroga-Roger, D.; Bustamante, A.; Vega, M.; Baez, M.; Puchner, E.M.; Wilson, C.A.M. Single molecule force spectroscopy reveals the effect of BiP chaperone on protein folding. Protein Science. 26 (7), 1404-1412, 2017. DOI: 10.1002/pro.3137

Aaron J. Paredes, Tatiana Naranjo-Palma, Hilda M. Alfaro-Valdés, Andrés Barriga, Jorge Babul, Christian A.M. Wilson. New visible and selective DNA staining method in gels with tetrazolium salts. Analytical Biochemistry: Methods in the Biological Sciences. 517 (2017), 31-35, 2017. DOI: 10.1016/j.ab.2016.11.004


Papers in collaboration

Mateluna, C., Torres, P., Rodriguez–Peña, M., Silva, P., Matthies, D. J., Criollo, A., ... & Torres, V. A. (2022). Identification of VEGFR2 as the Histatin–1 receptor in endothelial cells. Biochemical Pharmacology, 115079. DOI:

Francesca Burgos-Bravo, Samuel Martínez-Meza, Andrew F. G.Quest, Christian A. M. Wilson and Lisette Leyton. Application of Force to a Syndecan-4 Containing Complex With Thy-1–αVβ3 Integrin Accelerates Neurite Retraction. DOI:

Daniel Peña-Oyarzun, Marcelo Rodriguez-Peña, Francesca Burgos-Bravo, Angelo Vergara, Catalina Kretschmar, Cristian Sotomayor-Flores, Cesar A. Ramirez-Sarmiento, Humbert De Smedt, Montserrat Reyes, William Perez, Vicente A. Torres, Eugenia Morselli, Francisco Altamirano, Christian A. M. Wilson, Joseph A. Hill, Sergio Lavandero & Alfredo Criollo. PKD2/polycystin-2 induces autophagy by forming a complex with BECN1. Autophagy 2020. DOI:

Diaz-Dinamarca, D.A.; Manzo, R.A.; Soto, D.A.; Avendaño-Valenzuela, M.J.; Bastias, D.N.; Soto, P.I.; Escobar, D.F.; Vasquez-Saez, V.; Carrión, F.; Pizarro-Ortega, M.S.; Wilson, C.A.M.; Berrios, J.; Kalergis, A.M.; Vasquez, A.E. Surface Immunogenic Protein of Streptococcus Group B is an Agonist of Toll-Like Receptors 2 and 4 and a Potential Immune Adjuvant. Vaccines 2020, 8, 29. DOI: 10.3390/vaccines8010029

Nathalie Casanova-Morales, Nataniel L. Figueroa, Karol Alfaro, Felipe Montenegro, Nelson P. Barrera, J. R. Maze, Christian A. M. Wilson, Pablo Conejeros. Structural characterization of the saxitoxin-targeting APTSTX1 aptamer using optical tweezers and molecular dynamics simulations. PloS ONE. 2019, 14(11) DOI: 10.1371/journal.pone.0222468

Nathalie Casanova-Morales, Zahra Alavi, Christian A.M. Wilson, and Giovanni Zocchi. Identifying Chaotropic and Kosmotropic Agents by Nanorheology. J. Phys. Chem. B, 2018, 122 (14), pp 3754–3759. DOI: 10.1021/acs.jpcb.7b12782

Andrés Bustamante, Juan Carlos Sotelo, Daniel G. Guerra, Martin Floor, Christian A.M. Wilson, Carlos Bustamante, Mauricio Baez. The Energy Cost of Polypeptide Knot Formation and its Folding Consequences. Nature Communications. 8(1), 1581, 2017. DOI: 10.1038/s41467-017-01691-1

Burgos-Bravo, F.; Figueroa, N.L.; Casanova-Morales, N.; Quest, A.F.G.; Wilson, C.A.M.*; Leyton, L.* Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using non-purified proteins. Molecular Biology of the Cell. Recomendado para publicar con cambios menores: 05 de Junio de 2017.*co-corresponding author. DOI: 10.1091/mbc.E17-03-0133

Muñoz, R., Aguilar, F., Wilson, C.A.M., Melo, F. Pulling on super paramagnetic beads with micro cantilevers: single molecule mechanical assay application. Physical Biology.12 (4), 046011, 2015. DOI: 10.1088/1478-3975/12/4/046011